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Robert Hänsel-Hertsch

Epigenetic determinants of genome stability for mammalian tissue

Welcome to our "Buddy Program", a vital initiative designed to empower young female scientists in navigating the often challenging and highly competitive world of scientific research. In this supportive network, aspiring scientists have the opportunity to connect with experienced Principal Investigators, creating a safe space to openly discuss the obstacles they face, share insecurities and fears, and seek guidance to conquer the hurdles on their path to success.

In an environment where knowledge and wisdom meet enthusiasm and ambition, our program fosters mentorship that transcends generations and promotes diversity in the scientific community. Here, young minds can gain insights, strategies, and encouragement from those who have blazed trails before them, ultimately equipping them with the tools needed to reach their full potential in the scientific realm. Together, we aim to make science more inclusive, encouraging young female scientists to soar to new heights and to make their mark on the ever-evolving landscape of research

PROJECT RELATED PUBLICATIONS 

  1. Hunold P*, Hoehne MN*, Kiljan M, van Ray O, Herter J, Herter-Sprie GS, Hänsel-Hertsch R. G-quadruplex DNA structures mediate non-autonomous instruction of breast tumour microenvironments. bioRxiv 2023 https://doi.org/10.1101/2023.01.16.524243. *contributed equally
  2. Hänsel-Hertsch R, Simeone A, Shea A, Hui WWI, Zyner KG, Marsico G, Rueda OM, Bruna A, Martin A, Zhang X, Adhikari S, Tannahill D, Caldas C, Balasubramanian S. Landscape of G-quadruplex DNA structural regions in breast cancer. Nat Genet. 2020 Sep;52(9):878-883. doi: 10.1038/s41588-020-0672-8. Epub 2020 Aug 3. PMID: 32747825
  3. Hänsel-Hertsch R, Spiegel J, Marsico G, Tannahill D, Balasubramanian S. Genome-wide mapping of endogenous G-quadruplex DNA structures by chromatin immunoprecipitation and high-throughput sequencing. Nat Protoc. 2018 Mar;13(3):551-564. doi: 10.1038/nprot.2017.150. Epub 2018 Feb 22. PMID: 29470465
  4. Hänsel-Hertsch R, Di Antonio M, Balasubramanian S. DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential. Nat Rev Mol Cell Biol. 2017 May;18(5):279-284. doi: 10.1038/nrm.2017.3. Epub 2017 Feb 22. PMID: 28225080
  5. Hänsel-Hertsch R, Beraldi D, Lensing SV, Marsico G, Zyner K, Parry A, Di Antonio M, Pike J, Kimura H, Narita M, Tannahill D, Balasubramanian S. G-quadruplex structures mark human regulatory chromatin. Nat Genet. 2016 Oct;48(10):1267-72. doi: 10.1038/ng.3662. Epub 2016 Sep 12. PMID: 27618450