FOR5504: A joint genome stability research hub
The Research Unit aims to shed new light onto the fundamental role of genome maintenance in the organism’s homeostasis. Dissecting the mechanisms through which genome instability compromises cellular function will provide new perspectives for our understanding of the causes of aging and the full range of chronic age-related diseases. This transformative endeavor implements state of the art methodologies ranging from genetics and biochemistry to bioinformatics and computational biology.
The FOR 5504 combines internationally renowned expertise in genome stability research at the campus of the University Hospital of Cologne. Working in close vicinity at the CECAD Research Center, the Center for Molecular Medicine, and the Max Planck Institute for Biology of Aging, a multidisciplinary consortium that also includes the Max Planck Institute for Molecular Biomedicine in Münster set out to push the frontiers in understanding genome maintenance in the context of the organismal homeostasis. The individual labs of the Research Units have each made important contributions to the state of the art in the field of genome stability and combine a unique expertise that range from DNA repair mechanisms, epigenetic regulation and proteostasis to the pathophysiology of genome instability.
We are convinced that our approach will ultimately shed new light on unknown aspects of the physiological causes and consequences of genome instability.
The Research unit 5504 is funded by the Deutsche Forschungsgemeinschaft
The following institutions are affiliated with the FOR5504
