PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

The newly established Research Unit 5504 funded by the German Research Foundation DFG is pursuing a highly innovative program that aims to understand the physiological causes and consequences of genome instability. The ultimate goal of the Research Unit is to understand both how homeostatic processes affect genome stability and how the DDR maintains the physiological integrity of the organism in the face of DNA damage.

To this end, we assembled a team of leading researchers that all focus on in vivo studies of genome stability using animal models. The research unit will bridge the knowledge gap between causes of genome instability such as transcription-blocking lesions, DNA strand breaks, telomere dysfunction, mechanical stress and structural elements such as G-quadruplexes, and the response mechanisms that determine how genome instability affects cellular and organismal homeostasis

Projects

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Upcoming Events

Seminar Series

Do · 14.11.2024

"Repair of DNA double-strand by non-homologous end-joining"

Speaker: Markus Löbrich (TU Darmstadt)

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Seminar Series

Do · 28.11.2024

MD fellowship project reports

Speakers: Giuseppe Oppedisano and Lukas Koch

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Seminar Series

Mo · 09.12.2024

Coordination of DNA damage response and aging by ubiquitin signaling

Speaker: Maria Pandrea (Thorsten Hoppe)

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Seminar Series

Do · 12.12.2024

Epigenetic Regulation of Cellular Homeostasis Amid Transcription-Blocking DNA Damage During Development and Aging, project 3

Speaker: Angelina Job Kolady (Yao Wang)

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Seminar Series

Do · 16.01.2025

"tba"

Speaker: Jörg Kobarg (University of Campinas)

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Seminar Series

Do · 23.01.2025

"The role of the DNA damage response in renal ciliopathies"

Guest: Gisela Slaats, UMC Utrecht

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Seminar Series

Do · 13.02.2025

"Genome Instability Syndromes as a Toolbox to Unravel Novel DNA Repair Pathways", (project 5)

Speaker: Maxim Hützen

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Seminar Series

Do · 27.02.2025

"tba"

Guest: Daphne Selvaggia Cabianca (Helmholtz Institute Munich)

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Seminar Series

Do · 13.03.2025

"tba"

Guest: Roderick O'Sullivan (UPMC Hillman Pittsburgh)

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FOR 5504
Universitätsklinik Köln
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Köln
Tel. +49 (0)221 478 84198
simon.uszkoreit@uk-koeln.de