PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

The newly established Research Unit 5504 funded by the German Research Foundation DFG is pursuing a highly innovative program that aims to understand the physiological causes and consequences of genome instability. The ultimate goal of the Research Unit is to understand both how homeostatic processes affect genome stability and how the DDR maintains the physiological integrity of the organism in the face of DNA damage.

To this end, we assembled a team of leading researchers that all focus on in vivo studies of genome stability using animal models. The research unit will bridge the knowledge gap between causes of genome instability such as transcription-blocking lesions, DNA strand breaks, telomere dysfunction, mechanical stress and structural elements such as G-quadruplexes, and the response mechanisms that determine how genome instability affects cellular and organismal homeostasis

Projects

Show all projects

Upcoming Events

Seminar Series

Do · 18.07.2024

"Mechanism of genetic quality control in germ cells"

Guest: Dr. Volker Dötsch

Learn more

Seminar Series

Do · 25.07.2024

"AGE-RELATED LOSS OF HETEROCHROMATIN IN OOCYTES AND GRANULOSA CELLS AND ITS ASSOCIATED FERTILITY OUTCOMES"

Guest: Dr. Michael Klutstein

Learn more

Seminar Series

Mi – Fr | 25. – 27.09.2024

DNA Repair Meeting 2024 (DGDR)

Learn more

Seminar Series

Do · 10.10.2024

"Mechanism and consequences of SLX4IP- and ERCC1-XPF-dependent telomere dysfunction", (project 6)

Speaker: Francesca Pandolfo, Stephanie Panier

Learn more

FOR 5504
Universitätsklinik Köln
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Köln
Tel. +49 (0)221 478 84198
simon.uszkoreit@uk-koeln.de