PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

The newly established Research Unit 5504 funded by the German Research Foundation DFG is pursuing a highly innovative program that aims to understand the physiological causes and consequences of genome instability. The ultimate goal of the Research Unit is to understand both how homeostatic processes affect genome stability and how the DDR maintains the physiological integrity of the organism in the face of DNA damage.

To this end, we assembled a team of leading researchers that all focus on in vivo studies of genome stability using animal models. The research unit will bridge the knowledge gap between causes of genome instability such as transcription-blocking lesions, DNA strand breaks, telomere dysfunction, mechanical stress and structural elements such as G-quadruplexes, and the response mechanisms that determine how genome instability affects cellular and organismal homeostasis

Projects

Show all projects

Upcoming Events

Seminar Series

Do · 12.12.2024

Epigenetic Regulation of Cellular Homeostasis Amid Transcription-Blocking DNA Damage During Development and Aging, project 3

Speaker: Angelina Job Kolady (Yao Wang)

Learn more

Seminar Series

Do · 09.01.2025

"title: tba"

Speaker: Lukasz Kaczmarczyk

Seminar Series

Do · 16.01.2025

"title: tba"

Speaker: Jörg Kobarg (University of Campinas)

Learn more

Seminar Series

Do · 23.01.2025

"The role of the DNA damage response in renal ciliopathies"

Guest: Gisela Slaats, UMC Utrecht

Learn more

Seminar Series

Do · 13.02.2025

"title: tba", (affiliated group leader)

Speaker: Valentina Piano

Learn more

Seminar Series

Do · 27.02.2025

"title: tba"

Guest: Daphne Selvaggia Cabianca (Helmholtz Institute Munich)

Learn more

Seminar Series

Do · 13.03.2025

"title: tba"

Guest: Roderick O'Sullivan (UPMC Hillman Pittsburgh)

Learn more

Seminar Series

Do · 27.03.2025

"Mechanical-stress induced DNA damage and genome mechanoprotection in cellular and organismal homeostasis", (project 2)

Speaker: Anja Michelbach (Sara Wickström)

Learn more

Seminar Series

Do · 10.04.2025

A damage driven transcription stress on aging and the effect of calorie restriction, (project 7)

Speaker: Joris Demmer (Jan Hoeijmakers)

Learn more

Seminar Series

Do · 24.04.2025

"DNA Damage Tolerance: Physiological and Cancer Therapeutic Relevance"

Guest: Heinz Jacobs (Netherlands Cancer Institute Antoni Van Leeuwenhoek)

Learn more

FOR 5504
Universitätsklinik Köln
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Köln
Tel. +49 (0)221 478 84198
simon.uszkoreit@uk-koeln.de