PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

PHYSIOLOGICAL CAUSES AND CONSEQUENCES OF GENOME INSTABILITY

The newly established Research Unit 5504 funded by the German Research Foundation DFG is pursuing a highly innovative program that aims to understand the physiological causes and consequences of genome instability. The ultimate goal of the Research Unit is to understand both how homeostatic processes affect genome stability and how the DDR maintains the physiological integrity of the organism in the face of DNA damage.

To this end, we assembled a team of leading researchers that all focus on in vivo studies of genome stability using animal models. The research unit will bridge the knowledge gap between causes of genome instability such as transcription-blocking lesions, DNA strand breaks, telomere dysfunction, mechanical stress and structural elements such as G-quadruplexes, and the response mechanisms that determine how genome instability affects cellular and organismal homeostasis

Projects

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Upcoming Events

Seminar Series

Do · 14.03.2024

"Epigenetic determinants of genome stability for mammalian tissue", (project 1)

Speaker: Anna Eva Koch, Robert Hänsel-Hertsch

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Seminar Series

Do · 28.03.2024

"tba"

Guest: Gisela Slaats, UMC Utrecht

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Seminar Series

Do · 11.04.2024

"Mechanism and consequences of SLX4IP- and ERCC1-XPF-dependent telomere dysfunction", (project 6)

Speaker: Francesca Pandolfo, Stephanie Panier

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Seminar Series

Do · 25.04.2024

"G-quadruplex DNA structures a curse and a blessing for genome stability"

Guest: Prof. Katrin Paeschke

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Seminar Series

Do · 23.05.2024

"tba"

Guest: Dr. Graeme Hewitt

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Seminar Series

Do · 13.06.2024

"ADP-ribosylation at the nuclear pore complex"

Speaker: Orsolya Leidecker

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Seminar Series

Do · 27.06.2024

"Metabolic deregulation, genome instability, and the progression of chronic kidney disease", (project 8)

Speaker: Bernhard Schermer, Thomas Benzing

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Seminar Series

Do · 11.07.2024

"Unravelling the role of RPA4 in genome stability using the naked mole-rat physiology."

Speaker: Maria Sol Jacome Burbano

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Seminar Series

Do · 25.07.2024

"tba"

Guest: Dr. Michael Klutstein

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FOR 5504
Universitätsklinik Köln
CECAD Research Center
Joseph-Stelzmann-Str. 26
50931 Köln
Tel. +49 (0)221 478 84198
simon.uszkoreit@uk-koeln.de